| Name | Magnesium sulphate regimens for women with eclampsia: messages from the Collaborative Eclampsia Tria |
| Description | Eclampsia remains an important cause of maternal mortality throughout the world. Although it has long been standard practice to use an anticonvulsant for the care of women with eclampsia, the choice .of agent has been controversial for more than 70 years. This situation changed recently with the publication of the Collaborative Eclampsia Trial, involving nearly 1700 women with eclampsia'. In this study, roughly half the women were randomized to receive either magnesium sulphate or diazepam, and the other half were randomized to either magnesium sulphate or phenytoin. In the diazepam arm of the trial, women allocated magnesium sulphate had a 52 YO lower risk of recurrent convulsions (95 YO CI 64 % to 37 %) than those on diazepam. In the phenytoin arm, women allocated magnesium had a 67 YO lower risk of recurrent convulsions (95 YO CI 79 YO to 47%) than those on phenytoin. There is now, for the first time, compelling evidence in favor of magnesium sulphate, rather than diazepam or phenytoin, for the treatment of women with eclampsia. |
| Tag | MCHIP, article, English, magnesium sulphate, maternal health, eclampsia, obstetricians, regular intramuscular, (IM), myoneural junction |
| Filename | duley_magnesium_sulphate_regimens_bjog_1996.pdf |
| Filesize | 298,72 kB |
| Filetype | pdf (Mime Type: application/pdf) |
| Creator | christopherlindahl |
| Created On: |
06/28/2010 17:17 |
| Viewers | Everybody |
| Maintained by | Editor |
| Hits | 1821 Hits |
| Last updated on |
08/03/2011 17:14 |
| Homepage | http://www.jhpiego.jhu.edu/ |
