Guatemalan women, their families, and their neighbors exposed to an innovative safe motherhood program now know what to do in case something goes wrong during pregnancy, childbirth, or postpartum. Recognizing obstetrical emergencies and taking appropriate action are the goals of the Guatemalan Ministry of Health and Public Assistance (MOH) and the Maternal and Neonatal Health Program (MNH) implemented by JHPIEGO, an affiliate of Johns Hopkins University, and John Hopkins Bloomberg School of Public Health/Center for Communication Programs (CCP). The U.S. Agency for International Development supports the MNH Program through its Guatemala-Central American Program. Taking action in a timely manner helps save women’s lives and reduce maternal mortality.